[BioC] tandem MS question

David Lee Duewer david.duewer at nist.gov
Thu Dec 2 00:27:29 CET 2004

> From: Xiaochun Li <xiaochun at jimmy.harvard.edu>
> To: bioconductor at stat.math.ethz.ch
> Sent: Wednesday, December 01, 2004 5:33 PM
> Subject: [BioC] tandem MS question
> Do some of you have experience working with tandem-ms
> data for biomarker discovery (not for sequencing/identification
> as it's often used)?
> The data at hand are generated with a HTP microspray
> peptide LC then into Tandem MS. The biologist is looking
> at the 3D data of time by m/z by intensity (relative abundance)
> 'Time' resulted from the LC part separates proteins by their
> hydrophobic properties. So this kind of data has one extra
> dimension 'time' than the MALDI/SELDI spectra.

You might want to investigrate the "chemometric" multi-way (also called
N-way) analysis techniques.  Excellent sources for information and software
www.models.kvl.dk/users/rasmus/ and www.eigenvector.com


David Lee Duewer
National Institute of Standards and Technology
100 Bureau Drive Stop 8390
Gaithersburg, MD  20899-8390

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