[BioC] [Re] Filtering by Fold Change
Peter.Robinson at t-online.de
Mon Jun 28 20:29:49 CEST 2004
Thanks to all who have sent comments and suggestions. I would like to ask one
more question. I am doing the filtering to prepare a dataset for some several
class discovery methods that blow up with relatively large datasets. I have
about 60 tumor samples coming from 7 known biological classes, but comparing
the means of these groups to look at fold change would bias the method.
Assuming intersample normalization is it justified to compare the overall
highest with the overall lowest as a fold change measure or is there a better
way of doing this?
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