[BioC] Rocke-Lorenzato model or Global Error Model in Bioconductor

Greg Finak finak at mcb.mcgill.ca
Thu Dec 8 23:19:39 CET 2005

The closest thing to the two component error model you're referring  
to (I think)  is the Rocke, Durbin model (Bioinformatics, 2003, 19,  
966-972). The last time I checked, there was code on David Rocke's  
web site. I think I've seen an R package there as well. Otherwise,  
still within the microarray framework, there's the VSN package, which  
performs essentially the same job (variance stabilization). I'd  
suggest reading any vignettes or user manuals available for the  
packages to get a handle on using the code. You may also want to look  
at the original papers.


Greg Finak
PhD Candidate
McGill Center For Bioinformatics

W: (514)398-7071 x09317
emai: finak at mcb.mcgill.ca

On 6-Dec-05, at 6:54 PM, Ruppert Valentino wrote:

> Hello,
> I wonder if anyone knows what is the nearest thing to the Globel  
> Error Model
> (two-component (Rocke-Lorenzato) error model) in Bioconductor and  
> how to use
> it.
> I would like to compare the results I got in GeneSpring using the  
> Global
> Error Model using something similar in Bioconductor but wonder if a  
> pakcage
> for such model exist, if not is there anything that resemble it?
> Thanks,
> Raphael
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