[BioC] Fold Change values after RMA

[kfbargad@ehu.es]

Dear List,

I have come across an article (Choudary et al. 2005, PNAS 102,15653-
15658) where they state that the FC values after RMA 
preprocessing "always" remain below a maximum of 2.0 Is this right?

I have performed some analyses using RMA, quantile normalisation and 
limma and am getting M values higher than 2, and if M = log2(FC), then 
FC values are higher than 4. What am I missing? Any comments on this?

Thanks in advance,

David