[BioC] MaSigPro

[Mª José Nueda]

Hello,

We have an adaptation of maSigPro that applies the method to groups
of genes classified in similar categories. If you are interested in applying
this adaptation we can send you the script .

But if you apply the method to heterogeneous groups, the fitted model is not
going to be a good fit. Each gene can have its
own profile and obtaining a good model for significant, but different
genes can be impossible.
If you are interested in applying this adaptation, let me know and we
will send you.

Kind regards.

María.



----- Original Message ----- 
From: "Narinder Singh Sahni" <narinder at mail.jnu.ac.in>
To: <bioconductor at stat.math.ethz.ch>
Sent: Friday, October 26, 2007 10:47 AM
Subject: [BioC] MaSigPro


> Hei,
>
> I am using MaSigPro to analyze different sets of genes.
> Amongst the outputs provided in MaSigPro is R-sq, for each fitted gene .
>
> Is there a way to combine the significant genes in
> a single model and obtain a single measure of the variance explained, R-sq
(adj),
> using all the genes. My main aim is to be able to compare different
genesets, and
> if possible rank them in order of variance explained by each geneset.
>
> Maybe this is already provided for in the package, but I haven't been able
to figure it out.
> Are there any other packages in Bioconductor that might be useful for this
purpose.
>
> Thanks
>
> Narinder S. Sahni
>
> Narinder Singh Sahni
> Associate Professor
> School of Information Technology
> Jawaharlal Nehru University
> New Delhi - 110067
> India
> Ph: +91-11-26704173
> Fax: +91-11-26717586
>
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