[BioC] Can limma be used to the matched data?

Gordon K Smyth smyth at wehi.EDU.AU
Fri Aug 1 12:16:39 CEST 2008

limma User's Guide, Section 8.3 "Paired samples".

Adding covariates is no problem.

Best wishes

> Date: Thu, 31 Jul 2008 11:33:12 -0400
> From: "Chunyan Liu" <Chunyan.Liu at cchmc.org>
> Subject: [BioC] Can limma be used to the matched data?
> To: <bioconductor at stat.math.ethz.ch>
> Message-ID: <4891A2F80200000600532ADD at n6mcgw16.cchmc.org>
> Content-Type: text/plain; charset=US-ASCII
> Hi,
> Could someone tell me if limma can be used for matched data? If not, any 
> suggestions? The cases and controls were age, gender and race matched. I 
> could have just used paired t test and adjust for multiple comparisons. 
> But I would like the possibility to adjust for other covariates. Does 
> anyone have similar situation?
> Thanks.
> Chunyan Liu
> Biostatistician I
> Center for Epidemiology and Biostatistics
> Cincinnati Children's Hospital Medical Center
> 513-636-9763

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