[BioC] Very low P-values in limma
Gordon K Smyth
smyth at wehi.EDU.AU
Sat Oct 24 04:44:58 CEST 2009
On Sat, 24 Oct 2009, Gordon K Smyth wrote:
> Dear Paul,
> Give your consensus correlation value, limma is treating your within-array
> replicates as worth about 1/3 as much as replicates on independent arrays
> (because 1-0.81^2 is about 1/3).
Sorry, my maths is wrong. The effective weight of the within-array
replicates is quite a bit less than 1/3, given ndups=4 and cor=0.81.
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