[BioC] microarray analysis in R without replicates

Rainer Tischler rainer_t62 at yahoo.de
Tue Sep 22 21:16:16 CEST 2009

Dear all,

have received a microarray data set in standard Affymetrix CEL-format
consisting of only six samples  without any replicates (same organism
and cell type, but different individuals and different biological
conditions for each individual; the same Affymetrix GeneChip platform
was used for all samples). Moreover, the data was apparently collected
without any a-priori biological hypothesis.

I know that it is
impossible to apply standard clustering, feature selection or
classification techniques in this case. However, I am wondering whether
anybody is aware of a method in R to extract meaningful biological
information in this case (i.e. from single-sample microarray data or
from multiple samples with different biological conditions and no
replicates) - or is there nothing I can do given the above limitations?

Many thanks,

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