[BioC] using timecourse package with non-replicated time course

[Johannes Meisig]

Hi,

I have a developmental microarray time course with 18 time points under 
one biological condition but no replicates. I would like to rank genes 
in order of non-constancy.

The timecourse package seems well suited to this analysis. However, in 
the documentation it says nothing about the no replicate case. In Tai 
and Speed(1), it seems that the method still works in this special case. 
    Does anyone know if the timecourse package can be used in this case?

Thanks a lot,
Johannes

(1)
Tai and Speed, A Multivariate Empirical Bayes Statistic for Replicated 
Microarray Time Course Data, The Annals of Statistics, 34, 2006