[BioC] using timecourse package with non-replicated time course

Yu Chuan Tai yuchuan at stat.berkeley.edu
Fri Jul 15 04:02:07 CEST 2011

Hi Johannes,

Thanks for your interest in timecourse. However, the current timecourse 
only works for developmental longitudinal time course data *with* 
replicates. Therefore, it doesn't work for your data.

Hope this helps.

Yu Chuan

On Thu, 14 Jul 2011, Johannes Meisig wrote:

> Hi,
> I have a developmental microarray time course with 18 time points under
> one biological condition but no replicates. I would like to rank genes
> in order of non-constancy.
> The timecourse package seems well suited to this analysis. However, in
> the documentation it says nothing about the no replicate case. In Tai
> and Speed(1), it seems that the method still works in this special case.
>   Does anyone know if the timecourse package can be used in this case?
> Thanks a lot,
> Johannes
> (1)
> Tai and Speed, A Multivariate Empirical Bayes Statistic for Replicated
> Microarray Time Course Data, The Annals of Statistics, 34, 2006
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