[BioC] Comparing log FC edgeR

Gordon K Smyth smyth at wehi.EDU.AU
Fri Jul 5 01:55:46 CEST 2013


Dear Al,

Use edgeR glm (glmFit), and do a likelihood ratio test (glmLRT) of the 
appropriate contrast.

Best wishes
Gordon

> Date: Thu, 4 Jul 2013 04:20:17 -0500
> From: Alpesh Querer <alpeshq at gmail.com>
> To: Bioconductor mailing list <bioconductor at r-project.org>
> Subject: [BioC] Comparing log FC edgeR
>
> Hi all,-
>
> I want to compare logFC value from the output of exactTest function in edgeR
> for two different comparisons for each gene. So I have 4 conditions and I
> am testing if logFC for conditions 1 and 2 in that order is the same as
> logFC for conditions 3 and 4 in that order. What will be the right
> statistical test and is there a function in R to do this?
>
> Thanks
> Al

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