[BioC] about coverage profile comparison

[Wolfgang Huber]

Dear Raffaele

since coverage is simply a vector along genomic coordinates, would perhaps the basic vector arithmetic from R's base package, or perhaps the Rle class from the IRanges package be applicable?

	Best wishes
	Wolfgang

On 10 Sep 2013, at 08:36, rcaloger <raffaele.calogero at gmail.com> wrote:

> Hi,
> I am investigating the interplay of different isoforms, in alternative splicing differential expression.
> I would like to compare coverage profiles of the same isoform with or without the presence of the other isoforms, there is any tool, in bioconductor, that allows manipulation of coverage profile, e.g. subtraction of a profile to an other or comparison between different coverage profiles?
> Cheers
> Raffaele
> 
> -- 
> 
> ----------------------------------------
> Prof. Raffaele A. Calogero
> Bioinformatics and Genomics Unit
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