[BioC] Basic question re: multiple testing

[A.J. Rossini]

"Claire Wilson" <ClaireWilson at picr.man.ac.uk> writes:

> Apologies if this is slightly off-topic/bit basic! With respects to
> multiple testing, if you apply it does it change the actual order of
> significance, i.e. are your top 10 most significantly changing genes
> the same when you perform a t-test with multiple testing and when you
> apply a t-test without multiple testing?

It depends on the particular adjustment used, and how it rellocates
type I error in the hypothesis test.  So, yes and no.

best,
-tony

-- 
A.J. Rossini rossini at u.washington.edu http://software.biostat.washington.edu/ 
Biostatistics, U Washington and Fred Hutchinson Cancer Research Center

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